New jaspamide derivatives with antimicrofilament activity from the sponge Jaspis splendans

Tetrahedron
2007.0

Abstract

A reinvestigation of Jaspis splendans afforded the novel compounds jaspamide D–G plus the known compounds jaspamide and jaspamides B and C. All compounds exhibited potent cytotoxic activities and were shown to cause microfilament disruption. Biological activity and structural elucidation are reported here.

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