The structures of four new sesterterpenoid compounds 1-4 isolated from a marine sponge of the genus Luffariella, collected from The Great Barrier Reef, Australia, have been determined by analysis of their 1H-nmr, 13C-nmr, ir, uv, and eims spectral data. The new metabolites 1-4 were found to co-occur with the compounds manoalide, secomanoalide, Z-neomanolaide [5], and E-neomanoalide.