New Teleocidin-Related Metabolites, (-)-7-Geranylindolactam-V and Blastmycetin F, from Streptoverticillium blastmyceticum

Journal of Natural Products
1994.0

Abstract

Two new teleocidin-related metabolites, (-)-7-geranylindolactam-V [2] and blastmycetin F [3], were isolated from fermentation broths of the actinomycete Streptoverticillium blastmyceticum NA34-17, and their structures were determined by spectroscopic methods. Compound 2 bound strongly to phorbol ester receptors in a mouse epidermal particulate fraction, suggesting that it is a potent in vivo tumor promoter comparable to teleocidins A-1 [4] and B-4 [5].

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