Identification of Phoslactomycin E as a Metabolite Inducing Hyphal Morphological Abnormalities in Aspergillus fumigatus IFO 5840

The Journal of Antibiotics
2007.0

Abstract

In our survey for antifungal compounds, a fermentation broth of Streptomyces sp. HA81-2 was found to inhibit the in vitro growth of Aspergillus fumigatus IFO 5840 accompanied by hyphal morphological abnormalities. One of the isolated antibiotics was identified as phoslactomycin E based on LC-MS and NMR spectral data. In a preliminary assay using the membrane fractions of A. fumigatus, phoslactomycin E was found to inhibit the activity of 1,3-beta glucan synthase.

Knowledge Graph

Similar Paper

Identification of Phoslactomycin E as a Metabolite Inducing Hyphal Morphological Abnormalities in Aspergillus fumigatus IFO 5840
The Journal of Antibiotics 2007.0
Identification of Phoslactomycin E as a Metabolite Inducing Hyphal Morphological Abnormalities in Aspergillus fumigatus IFO 5840
The Journal of Antibiotics 2007.0
Studies on new phosphate ester antifungal antibiotics phoslactomycins. I. Taxonomy, fermentation, purification and biological activities.
The Journal of Antibiotics 1989.0
Studies of new phosphate ester antifungal antibiotics phoslactomycins. II. Structure elucidation of phoslactomycins A to F.
The Journal of Antibiotics 1989.0
Phoslactomycins from <i>Streptomyces</i> sp. MLA1839 and Their Biological Activities
Journal of Natural Products 2013.0
Fumimycin:  A Peptide Deformylase Inhibitor with an Unusual Skeleton Produced by <i>Aspergillus </i><i>fumisynnematus</i>
Organic Letters 2007.0
Pseurotin A and 8-<i>O</i>-Demethylpseurotin A from<i>Aspergillus fumigatus</i>and Their Inhibitory Activities on Chitin Synthase
Bioscience, Biotechnology, and Biochemistry 1993.0
Fumifungin, a new antifungal antibiotic from Aspergillus fumigatus Fresenius 1863.
The Journal of Antibiotics 1987.0
Antimycins A10∼A16, Seven New Antimycin Antibiotics Produced by Streptomyces spp. SPA-10191 and SPA-8893
The Journal of Antibiotics 2005.0
Antimycins A10∼A16, Seven New Antimycin Antibiotics Produced by Streptomyces spp. SPA-10191 and SPA-8893
The Journal of Antibiotics 2005.0