<jats:title>Abstract</jats:title> <jats:p>A new bromotyrosine-derived metabolite, 20-N-methylpurpuramine E (1), was isolated from the marine sponge Pseudoceratina purpurea. The structure was elucidated by spectroscopic analysis. 20-N-Methylpurpuramine E (1) showed weak cytotoxicity against HeLa S3 cells.