<jats:title>Abstract</jats:title><jats:p>A novel N‐containing aristolane sesquiterpenoid compound, lepidamine (<jats:bold>1</jats:bold>), was isolated from the fruiting bodies of Basidiomycete <jats:italic>Russula lepida.</jats:italic> Its structure was established by spectroscopic means. It is the first aristolane‐type sesquiterpene alkaloid isolated from nature.