Chemistry of Saururus cernuus, V. Sauristolactam and Other Nitrogenous Constituents

Journal of Natural Products
1990.0

Abstract

Two aristololactam analogues were isolated from the extract of Saururus cernuus. One of these was the known aristololactam BII [1] (cepharanone B) and the other new, named sauristolactam [2], was shown to be the lactam of 10-aminomethyl-3-hydroxy-4-methoxyphenanthrene-1-carboxylic acid. Here we detail the first reported occurrence of compounds of the aristololactam group in the genus Saururus. Saururus cernuus L. (Saururaceae) is an aquatic weed from which two novel dineolignans named manassantins A and B have been isolated earlier and shown to exhibit significant neuroleptic activity (1,2). A series of other neolignans also have been isolated which represent a variety of structural types (3). This note deals with the isolation of two isomeric, nonlignoid, fluorescent compounds, designated initially as FA and FB, and their characterization.

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