Makaluvamine G, a cytotoxic pigment from an an Indonesian Sponge Histodermella sp.

Tetrahedron
1993.0

Abstract

A cytotoxic pigment, makaluvamine G (5), biogenetically derivable from tryptamine and tyramine and structurally related to the discorhabdins, was isolated from a sponge of the genus Histodermella collected in Indonesia. The compound displays significant in vitro cytotoxicity to several tumor cell lines and is a moderate inhibitor of topoisomerase I, DNA, RNA, and protein synthesis.

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