Literature

Abstract

WAP-8294A, produced by Lysobacter sp., is a complex consisting of water soluble depsipeptide antibiotics. It was further purified by column chromatographies and HPLC, and 19 components were obtained. WAP-8294A2, a major component, and minor components A1, A4, Ax8, Ax9 and Ax13 were active against gram-positive bacteria, in particular, methicillin-resistant Staphylococcus aureus (MRSA) in vitro. WAP-8294A2 was highly active in vivo in mice against the systemic infection of MRSA.

DOI： 10.7164/ANTIBIOTICS.51.929

A New Anti-MRSA Antibiotic Complex, WAP-8294A. I. Taxonomy, Isolation and Biological Activities.

The Journal of Antibiotics 1998.0

Identification and Characterization of the Anti-Methicillin-Resistant Staphylococcus aureus WAP-8294A2 Biosynthetic Gene Cluster from Lysobacter enzymogenes OH11

Antimicrobial Agents and Chemotherapy 2011.0

Identification of an Anti-MRSA Cyclic Lipodepsipeptide, WBP-29479A1, by Genome Mining of <i>Lysobacter antibioticus</i>

Organic Letters 2019.0

Tripropeptins, Novel Antimicrobial Agents Produced by Lysobacter sp. I. Taxonomy, Isolation and Biological Activities.

The Journal of Antibiotics 2001.0

Mersacidin, a new antibiotic from Bacillus Fermentation, isolation, purification and chemical characterization.

The Journal of Antibiotics 1992.0

A54145, a new lipopeptide antibiotic complex. Isolation and characterization.