The latex of Euphorbia obtusifolia var. obtusifolia yielded twelve new diterpene polyesters. Seven of them displayed the jatrophane framework and ®ve were 4-deoxyphorbol esters. A further isolated tigliane diterpene, a derivative of 4-epi-4 deoxyphorbol, was most likely an artifact of the isolation procedure. All structures were established with the aid of spectroscopic methods.