Further phytochemical investigation of Sanchezia nobilis Hook.f. (Acanthaceae) has afforded nine compounds, the cinnamyl alcohol glycosides: 9-O--glucopyranosyl trans-cinnamyl alcohol (1), 9-O--xylopyranosyl- (16)-O--glucopyranosyl-(16)-O--glucopyranosyl trans-cinnamyl alcohol (2), and syringin (3); the neolignan glucoside: 4-O--glucopyranosyl dehydrodiconiferyl alcohol (4); the benzyl alcohol glycosides: 7-O--glucopyranosyl benzyl alcohol (5) and 7-O--apiofuranosyl-(16)-O--glucopyranosyl benzyl alcohol (6), together with the flavonoid glycosides: apigenin-7-O--glucopyranoside (7), apigenin-7-Ogentiobioside (8), and apigenin-7-O--glucuronopyranoside (9). Compound 2 is isolated here for the first time from a natural source, compounds 1, 3, 4, and 8 have been isolated for the first time from the family Acanthaceae, while compounds 5–7 and 9 are reported for the first time from the genus Sanchezia.