A Family of Nonribosomal Peptides Modulate Collective Behavior in Pseudovibrio Bacteria Isolated from Marine Sponges**

Angewandte Chemie International Edition
2021.0

Abstract

<jats:title>Abstract</jats:title><jats:p>Although swarming motility and biofilms are opposed collective behaviors, both contribute to bacterial survival and host colonization. <jats:italic>Pseudovibrio</jats:italic> bacteria have attracted attention because they are part of the microbiome of healthy marine sponges. Two‐thirds of <jats:italic>Pseudovibrio</jats:italic> genomes contain a member of a nonribosomal peptide synthetase‐polyketide synthase gene cluster family, which is also found sporadically in <jats:italic>Pseudomonas</jats:italic> pathogens of insects and plants. After developing reverse genetics for <jats:italic>Pseudovibrio</jats:italic>, we isolated heptapeptides with an ureido linkage and related nonadepsipeptides we termed pseudovibriamides A and B, respectively. A combination of genetics and imaging mass spectrometry experiments showed heptapetides were excreted, promoting motility and reducing biofilm formation. In contrast to lipopeptides widely known to affect motility/biofilms, pseudovibriamides are not surfactants. Our results expand current knowledge on metabolites mediating bacterial collective behavior.

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