A mixture of secoisolariciresinol lignans acylated at C-9 and C-9' with dodecanoic, tetradecanoic and hexadecanoic acids, the triterpenes 3-oxo-tirucalla-7,24diene and 3,21-dioxo-tirucalla-7,2~diene, and the steroids sitosterol, stigmasterol, campesterol, sitostenone, sti~astenone and campestenone were isolated from the stems of Simaba cuneuta. Their structures were established based on full spectral analysis and chemical methods.