<jats:title>Abstract</jats:title><jats:p>Phytochemical investigation of the stems of <jats:italic>Bruguiera sexangula</jats:italic> var. <jats:italic>rhynchopetala</jats:italic> resulted in the isolation and characterization of four new and seven known secondary metabolites. The new compounds were spectroscopically identified as 17‐hydroxy‐16‐oxobeyer‐9(11)‐en‐19‐al (<jats:bold>1</jats:bold>), 16,17‐dihydroxy‐19‐nor‐<jats:italic>ent</jats:italic>‐kaur‐9(11)‐en‐3‐one (<jats:bold>2</jats:bold>), (16<jats:italic>R</jats:italic>)‐13,17‐epoxy‐16‐hydroxy‐<jats:italic>ent</jats:italic>‐kaur‐9(11)‐en‐19‐al (<jats:bold>3</jats:bold>), and (−)‐3,4‐dihydro‐3‐hydroxy‐7‐methoxy‐2<jats:italic>H</jats:italic>‐1,5‐benzodithiepine‐6,9‐dione (<jats:bold>10</jats:bold>). The configurations of the known compounds brugierol (<jats:bold>11</jats:bold>) and isobrugierol (<jats:bold>12</jats:bold>) were re‐investigated. Compounds <jats:bold>11</jats:bold> and <jats:bold>12</jats:bold>, together with 2,6‐dimethoxy‐1,4‐benzoquinone (<jats:bold>13</jats:bold>), are proposed to be degradation products of the novel, unusual disulfide <jats:bold>10</jats:bold> (<jats:italic>Scheme</jats:italic>).