Two new cyclodepsipeptides, geodiamolide H (3) and I (4), were isolated from the marine sponge Geodia sp. The structures of 3 and 4 were determined by 2D NMR spectroscopy while the absolute stereochemistry of 4 was established by X-ray crystallography. Geodiamolide H 3 was cytotoxic to some human cancer cell lines.