Globomycin, a new peptide antibiotic with spheroplast-forming activity. III. Structural determination of globomycin.

The Journal of Antibiotics
1978.0

Abstract

The structure of globomycin has been determined by mass, PMR and CMR spectra and by chemical degradation. Globomycin is a new cyclic peptide antibiotic composed of L-serine, L-allo-threonine, glycine, N-methylleucine, L-allo-isoleucine and 3-hydroxy-2-methylnonaic acid. Among these components, L-allo-threonine, L-allo-isoleucine and 3-hydroxy-2-methylnonaic acid are novel components from natural products. A newly developed mass analysis has been introduced for determining the diastereoisomers of allo-threonine.

DOI： 10.7164/ANTIBIOTICS.31.426

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