Codinaeopsin, an Antimalarial Fungal Polyketide

Organic Letters
2008.0

Abstract

A new tryptophan-polyketide hybrid, codinaeopsin, was isolated from an endophytic fungus collected in Costa Rica. The structure of codinaeopsin, which was deduced from NMR and mass spectral data, contains an unusual heterocyclic unit linking indole and decalin fragments. Codinaeopsin is active against Plasmodium falciparum, the causative agent of the most lethal form of malaria (IC50 = 2.3 microg/mL or 4.7 microM).

Knowledge Graph

Similar Paper