SB-253514 and Analogues. Novel Inhibitors of Lipoprotein-Associated Phospholipase A2 Produced by Pseudomonas fluorescens DSM 11579. I. Fermentation of Producing Strain, Isolation and Biological Activity.

The Journal of Antibiotics
2000.0

Abstract

Two new classes of inhibitors of LpPLA2 have been identified in fermentations of Pseudomonas fluorescens. The two structurally isomeric series differ in the geometry of closure of the bicyclic carbamate and comprise a range of compounds varying only in length of their lipophilic sidechain. The most abundant species were extracted from the cells and purified by silica and C18 chromatography. Members of the more stable class were shown to be potent and selective competitive inhibitors of LpPLA2.

Knowledge Graph

Similar Paper

SB-253514 and Analogues. Novel Inhibitors of Lipoprotein-Associated Phospholipase A2 Produced by Pseudomonas fluorescens DSM 11579. I. Fermentation of Producing Strain, Isolation and Biological Activity.
The Journal of Antibiotics 2000.0
SB-253514 and Analogues. Novel Inhibitors of Lipoprotein Associated Phospholipase A2 Produced by Pseudomonas fluorescens DSM 11579. II. Physico-chemical Properties and Structure Elucidation.
The Journal of Antibiotics 2000.0
SB-253514 and Analogues. Novel Inhibitors of Lipoprotein Associated Phospholipase A2 Produced by Pseudomonas fluorescens DSM 11579. III. Biotransformation Using Naringinase.
The Journal of Antibiotics 2000.0
Two new inhibitors of phospholipase A2 produced by Penicillium chermesinum. Taxonomy, fermentation, isolation, structure determination and biological properties.
The Journal of Antibiotics 1985.0
WA8242A1, A2 and B, Novel Secretory Phospholipase A2 Inhibitors Produced by Streptomyces violaceusniger. I. Taxonomy, Production and Purification.
The Journal of Antibiotics 1998.0
Design of new potent and selective secretory phospholipase A2 inhibitors. Part 5: Synthesis and biological activity of 1-alkyl-4-[4,5-dihydro-1,2,4-[4H]-oxadiazol-5-one-3-ylmethylbenz-4′-yl(oyl)] piperazines
Bioorganic & Medicinal Chemistry 2008.0
Panclicins, novel pancreatic lipase inhibitors. I. Taxonomy, fermentation, isolation and biological activity.
The Journal of Antibiotics 1994.0
Synthesis and Phospholipase A<sub>2</sub> Inhibitory Activity of Thielocin B3 Derivatives
Journal of Medicinal Chemistry 1996.0
5-Hydroxyanthranilic acid derivatives as potent 5-lipoxygenase inhibitors.
The Journal of Antibiotics 1993.0
5-Hydroxyanthranilic acid derivatives as potent 5-lipoxygenase inhibitors.
The Journal of Antibiotics 1993.0