Xestoproxamines A−C from Neopetrosia proxima. Assignment of Absolute Stereostructure of Bis-piperidine Alkaloids by Integrated Degradation-CD Analysis

Journal of Natural Products
2011.0

Abstract

The complete stereostructures of xestoproxamines A-C, from the Bahamian sponge Neopetrosia proxima, were assigned from spectroscopic analysis, including MS, 2D NMR, and integrated degradation-CD analysis. Two new CD application protocols are described for defining absolute configuration: one for allylic methyl groups in branched chains and a second for the heterocyclic core bis-piperidine with specific applicability to other members of this class alkaloids--known for their stereoheterogeneity--and tertiary cyclic amines in general.

Knowledge Graph

Similar Paper