Studies on Cochleamycins, Novel Antitumor Antibiotics. III. Biosyntheses of Cochleamycins: Incorporation of 13C- and 2H-Labeled Compounds into Cochleamycins.

The Journal of Antibiotics
1996.0

Abstract

Biosynthetic studies using 13C- and 2H-labeled compounds revealed that the carbon skeletons of cochleamycins A and B were derived from eight acetic acid units and one propionic acid unit with the introduction of an acetoxy group at C-10, which was replaced by an isobutyryl residue derived from valine in cochleamycins A2 and B2.

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