Novel 2,5-dihydrofuryl-.GAMMA.-lactam derivatives from Hemerocallis fulva L. var. kwanzo regel.

Chemical and Pharmaceutical Bulletin
1990.0

Abstract

In the course of extensive studies on the distribution of furostanol glycosides, some unidentified compounds from Hemerocallis plants, Liliaceae, were detected on thin-layer chromatographs which showed reddish or bluish purple with Ehrlich reagent. This prompted an investigation of the methanol extract of Hemerocallis fulva L. var. kwanzo Regel, Japanese name "Yabukanzo". We now report the extraction and structures of fulvanine A, B and C along with compound I. Three novel 2,5-dihydrofuryl-7-lactam derivatives, fulvanine A, B and C, have been extracted from Hemerocallis fulva L. var. kwanzo Regel along with compound I. Their respective structures have been established as 1-(3-hydroxymethyl-2,5-dihydrofuryl)-azacyclopenta-3,5-dihydroxy-2-one, 1-(3-methyl-2,5-dihydrofuryl)-azacyclopenta-3,5-dihydroxy-2-one and 1-(3-methyl-2,5-dihydrofuryl)-azacyclopenta-3-hydroxy-5-methoxy-2-one. Compound I was found its 1H and 13C-NMR spectra to be identical to oxypinnatanine.

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