Isolation and structure of koshikalide, a 14-membered macrolide from the marine cyanobacterium Lyngbya sp.

Tetrahedron Letters
2010.0

Abstract

A 14-membered macrolide, koshikalide (1), was isolated from the marine cyanobacterium Lyngbya sp., and its planar structure was elucidated by spectroscopic analysis. The relative stereochemistry of C-11 and C-13 was elucidated by NOESY experiments and by an analysis of 1 H–1 H coupling constants. Koshikalide (1) exhibited weak cytotoxicity against HeLa S3 cells.

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