A chemical study of the hexane extracts of the gorgonian octocoral Pseudopterogorgia elisabethae collected in San Andrés Island, Colombia, led to the isolation of two highly conjugated amphilectane-type diterpenes, compounds 1 and 2. Their structures were established by spectroscopic studies, which included 2D NMR correlation methods, IR, UV, and accurate mass measurements (HREIMS).