Bioactive Tyrosine‐Derived Cytochalasins from Fungus Eutypella sp. D‐1

Abstract

<jats:title>Abstract</jats:title><jats:p>Three new cytochalasins Z<jats:sub>24</jats:sub>, Z<jats:sub>25</jats:sub>, Z<jats:sub>26</jats:sub> (<jats:bold>1</jats:bold>–<jats:bold>3</jats:bold>, resp.) and one known compound, scoparasin B (<jats:bold>4</jats:bold>), were isolated from the fungus <jats:italic>Eutypella</jats:italic> sp. D‐1 isolated from the soil of high latitude of the Arctic. The structures of <jats:bold>1</jats:bold>–<jats:bold>3</jats:bold> were elucidated from spectroscopic data (NMR, MS). These compounds were evaluated for cytotoxic activities against several human tumor cell lines. Among them, compound <jats:bold>1</jats:bold> exhibited moderate cytotoxicity toward human breast cancer MCF‐7 cell line with <jats:italic>IC</jats:italic><jats:sub>50</jats:sub> of 9.33 μ<jats:sc>M</jats:sc>.