Marine microorganisms are recognized as an important source of structurally diverse bioactive secondary metabolites.1,2 Particularly, secondary metabolites from marine fungal isolates have attracted significant interest, as many of them provide unique structural features and interesting biological properties.2–4 In our search for new metabolites from marine-derived fungi, we recently reported the isolation of an anti-inflammatory metabolite named penicillinolide A from extracts obtained from cultures of a marine-derived isolate of Penicillium sp. (SF-5292).5 As part of our continuing efforts to explore the chemistry of this isolate, studies of extracts obtained from largerscale cultures of the fungus were undertaken. From this investigation, two minor metabolites, cycloexpansamines A (1) and B (2) were isolated (Figure 1) in addition to previously encountered penicillinolide A.