As a part of our extended work on the alkaloids of the plants belonging to the Rhamnaceae we have examined the stem bark of Z. nummularia. About a dozen cyclopeptide alkaloids have so far been reported from the root bark of Z. nummularia and the alkaloids nummularine-M, nummularine-N, and nummularine-O from the stem bark of this plant. Here we report the isolation and characterization of nummularine-P (1), a new cyclopeptide alkaloid, along with a known peptide alkaloid, mauritine-D, from the stem bark of Z. nummularia. The structure of nummularine-P was established by spectral analyses (ir, uv, ¹H nmr, ms), hydrolysis experiment, and formation of its N-formyl derivative, which differs from sativanine-C in having a leucine unit instead of isoleucine as an amino acid bound to the nitrogen of the styrylamine function. Mauritine-D was identified by spectral analysis, hydrolysis experiment, and direct comparison with authentic sample (co-tlc and superimposable ir).