The Palauan sponge Axinyssa aplysimoides contained (3S*,5R*,6R*,9R*)-3-isocyano-1(10)-cadinene[2],(3S*,5R*,6R*, 9R*)-3-formamido-1(10)-cadinene[3], and (E)-(4-hydroxystyryl)trimethylammonium chloride [6], together with the known diterpenes (-)-neoverrucosan-5beta-ol[4] and (+)-homoverrucosan-5beta-ol[5].