Eleven new angeloylated eudesmane sesquiterpenoids, dobinins D-N (<b>2</b>, <b>3</b>, <b>5</b>, <b>6</b>, <b>8</b>, <b>9</b>, and <b>11</b>-<b>15</b>), and four known compounds (<b>1</b>, <b>4</b>, <b>7</b>, and <b>10</b>) were isolated from the roots of <i>Dobinea delavayi</i>. A new oxidation product (<b>8a</b>) was also obtained from dobinin H (<b>8</b>). Their structures were elucidated by spectroscopic data and single-crystal X-ray diffraction analyses. Dobinins K-N (<b>12</b>-<b>15</b>) are the first examples of rearrangement noreudesmane analogue sesquiterpenoids with a unique 6/5-fused carbon skeleton. A putative biosynthetic pathway of compounds <b>12</b>-<b>15</b> is proposed. Compound <b>12</b> exhibited significant antimalarial activity superior to artemisinin with the inhibition ratio of 59.1%, and compounds <b>3</b>, <b>5</b>, and <b>15</b> exhibited moderate antimalarial activities against <i>Plasmodium yoelii</i> BY265RFP with inhibition ratios ranging from 14.5% to 18.5% at a dose of 30 mg/kg/day. In addition, the apoptosis of <i>P. yoelii</i> BY265RFP by the depolarization of mitochondrial membrane potential with striking ROS production, after parasitized erythrocyte lysis mediated by cytokines IL-12 and IFN-γ, may be a possible mechanism of antimalarial action of compound <b>12</b> against <i>P. yoelii</i> BY265RFP.