During the course of our screening for new antibiotics, we utilized sesame meal, a waste material from the industrial production of sasame oil, as a nitrogen source for growth of strains of Actinomycetes. An isolate of Streptomyces sp. IT-44 showed antibacterial and antitumor activities. Bioassay-guided fractionation of the broth filtrate of Streptomyces sp. IT-44 led to the isolation of three furofuran lignan-type antibiotics, determined as pinoresinol (1), epipinoresinol (2) and a new compound 3. Four related compounds, piperitol (4),tetrahydrofuran derivative (7) were also isolated by chemical screening. Those compounds were identified as relative compounds by their UVand XH NMRspectra. In this paper, we report the production, isolation and structure elucidation of the new lignans, compounds 3 and 7, named 6-hydroxypiperitol and sesaminone, respectively, shown in Fig.1.