Phloeodictines A1-A7 (3a, 3b, 4a, 4b, 4c, 5a, 5b) and phloeodictines C1-C2 (6a, 6b), new antibacterial and cytotoxic guanidine alkaloids, have been isolated from the sponge Phloeodictyon sp. Their structures were established essentially by mass spectrometry utilizing B/E linked scanning and by 2D NMR experiments