Chemical investigations of roots and leaves of Rhazya stricta have resulted in the isolation of the new indole alkaloids, 16R-19,20-E-isositsirikine acetate, leepacine and dihydroeburnamenine, along with six known alkaloids. Among these, (-)-16R,21R-O-methyleburnamine, 2-ethyl-3[2-(3-ethylpiperidino)ethyl]-indole, (20S)-19,20-dihydrocondylocarpine and N-acetylaspidospermidine have been isolated for the first time from R. stricta. Spectral studies on (+)-21S-eburnamenine and the glycoalkaloid strictosamide have also been undertaken. © 1991.