Acetylated DNA-damaging clerodane diterpenes from Casearia sylvestris1Part 3 in the series “Search for bioactive compounds from Brazilian plant species”. For part 2 see [2]. Based on the M.Sc. thesis submitted by P.R.F. de C. to Universidade Estadual Paulista (1997). Sponsored by CNPq.1

Phytochemistry
1998.0

Abstract

In addition to the known diterpene casearin G (1), two new clerodane diterpene casearins type, casearin S (2) and casearin T (3), were isolated from an acetylated bioactive CH2Cl2/MeOH extract from leaves of Casealia sylvestris. The diterpenes 1-3 exhibited moderate but selective activity towards the DNA-repair deficient yeast Saccharomyces cerevisiae mutants RAD 52YK and RS 321. The structures of 1-3 were established on the basis of NMR spectroscopic experiments (C) 1998 Elsevier Science Ltd. All rights reserved.

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