Bis(bibenzyls) from Liverworts Inhibit Lipopolysaccharide-Induced Inducible NOS in RAW 264.7 Cells:  A Study of Structure−Activity Relationships and Molecular Mechanism

Journal of Natural Products
2005.0

Abstract

The inhibition of lipopolysaccharide-induced NOS by 19 bis(bibenzyls) isolated from liverworts in RAW 264.7 macrophages was evaluated. The presence of phenolic hydroxyls and saturation at 7,8 and/or 7'/8' are required for inhibition of NO production. Among the compounds tested, marchantin A was the most potent, and its inhibitory activity was consistent with the inhibition of LPS-induced iNOS mRNA.

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