Three new rearranged phragmalin-type limonoids, named khayanolides A, B and C, were isolated as insect antifeedant together with four known rings B,D-seco compounds, seneganolide, methyl angolensate and its 6-hydroxy and 6-acetoxy derivatives from the ether extract of the stem bark of Khaya senegalensis. The structure of new compounds was elucidated by spectroscopic means and the absolute structure of khayanolide A was established by X-ray analysis and CD study. The antifeedant activity of the isolated compounds was also reported.