Pseudopyronines A and B, α-Pyrones Produced by a Marine Pseudomonas sp. F92S91, and Evidence for the Conversion of 4-Hydroxy-α-pyrone to 3-Furanone

Journal of Natural Products
2005.0

Abstract

In our search for inhibitors of bacterial fatty acid biosynthesis, two new alpha-pyrones, pseudopyronines A (1) and B (2), were isolated from a marine Pseudomonas sp. F92S91. The naturally occurring alpha-pyrones appeared to be unstable, evidenced by the conversion of pseudopyronine B into an oxidation product, 3-furanone (3). Structural elucidations were made by spectroscopic analyses including 2D-NMR data.

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