Novel Lactone Compounds from Mortierella verticillata that Induce the Human Low Density Lipoprotein Receptor Gene: Fermentation, Isolation, Structural Elucidation and Biological Activities.

The Journal of Antibiotics
1998.0

Abstract

Among methods of controlling hypercholesterolemia and hyperlipidemia is the direct stimulation of hepatic low density lipoprotein (LDL) receptors. Two novel lactone compounds, CJ-12,950 and CJ-13,357, containing and unusual oxime moiety, were isolated from a zygomycete Mortierella verticillata. These lactones are potent inducers of the LDL receptor gene in vitro, that enhanced LDL receptor expression in human hepatocytes 2-fold at 100 nM.

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