Okaramines S–U, three new indole diketopiperazine alkaloids from Aspergillus taichungensis ZHN-7-07

Tetrahedron
2015.0

Abstract

Three new indole diketopiperazine alkaloids, okaramines S-U (1-3), with two (1 and 2) of them prenylated, were obtained from the Aspergillus taichungensis ZHN-7-07. Their structures including the absolute configurations were determined by combination of NMR, MS, TDDFT ECD calculation, and Marfey's analysis. Okaramine S (1) showed the best cytotoxic activity against HL-60 cell with IC50 value of 0.78 mu M. (C) 2014 Elsevier Ltd. All rights reserved.

DOI： 10.1016/j.tet.2014.09.019

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