Diarylheptanoids from Curcuma kwangsiensis and their inhibitory activity on nitric oxide production in lipopolysaccharide-activated macrophages

Bioorganic & Medicinal Chemistry Letters
2011.0

Abstract

Eleven diarylheptanoids (1-11) were isolated from rhizomes of Curcuma kwangsiensis, together with seven known compounds. Their structures were elucidated by 1D and 2D NMR, circular dichroism (CD), and accurate mass measurements. Inhibitory effects of the isolated compounds on nitric oxide production in lipopolysaccaride-activated macrophages were evaluated. Compounds 1, 2, and 3 showed strong inhibitory activity on NO production with IC(50) values of 3.13, 2.81 and 2.41 μM, respectively.

Knowledge Graph

Similar Paper

Diarylheptanoids from Curcuma kwangsiensis and their inhibitory activity on nitric oxide production in lipopolysaccharide-activated macrophages
Bioorganic & Medicinal Chemistry Letters 2011.0
Diarylheptanoids from the Rhizomes of <i>Curcuma kwangsiensis</i>
Journal of Natural Products 2010.0
Guaiane-Type Sesquiterpenes from <i>Curcuma phaeocaulis</i> and Their Inhibitory Effects on Nitric Oxide Production
Journal of Natural Products 2013.0
iNOS Inhibitory Activity of Sesquiterpenoids and a Monoterpenoid from the Rhizomes of <i>Curcuma wenyujin</i>
Journal of Natural Products 2014.0
Anti-neuroinflammatory diarylheptanoids from the rhizomes of Dioscorea nipponica
Bioorganic &amp; Medicinal Chemistry Letters 2013.0
Cyclic diarylheptanoids from Myrica nana inhibiting nitric oxide release
Bioorganic &amp; Medicinal Chemistry 2008.0
Diarylheptanoid from <i>Pleuranthodium racemigerum</i> with <i>in Vitro</i> Prostaglandin E<sub>2</sub> Inhibitory and Cytotoxic Activity
Journal of Natural Products 2010.0
Inhibitory constituents of Nardostachys chinensis on nitric oxide production in RAW 264.7 macrophages
Bioorganic &amp; Medicinal Chemistry Letters 2012.0
Structures of New Cyclic Diarylheptanoids and Inhibitors of Nitric Oxide Production from Japanese Folk Medicine <i>Acer </i><i>n</i><i>ikoense</i>
Journal of Natural Products 2003.0
Phenanthrenes from Dendrobium nobile and their inhibition of the LPS-induced production of nitric oxide in macrophage RAW 264.7 cells
Bioorganic &amp; Medicinal Chemistry Letters 2010.0