Biosynthetic approach for the production of new aminoglycoside derivative

Biosynthetic approach for the production of new aminoglycoside derivative Combimicins,new kanamycin derivatives bioconverted by some Micromonosporas. MICROBIAL SEMI-SYNTHESIS OF AMINOGLYCOSIDIC ANTIBIOTICS BY MUTANTS OF S. RIBOSIDIFICUS AND S. KANAMYCETICUS Recent Biosynthetic Studies on Antibiotics Biosynthesis of spectinomycin: heterologous production of spectinomycin and spectinamine in an aminoglycoside-deficient host,<i>Streptomyces venezuelae</i>YJ003 A new aminoglycoside antibiotic, sannamycin C and its 4-N-glycyl derivative. Toward Overcoming Staphylococcus aureus Aminoglycoside Resistance Mechanisms with a Functionally Designed Neomycin Analogue Heterologous Production of Paromamine in Streptomyces lividans TK24 Using Kanamycin Biosynthetic Genes from Streptomyces kanamyceticus ATCC12853 An approach for cloning biosynthetic genes of 2-deoxystreptamine-containing aminocyclitol antibiotics: isolation of a biosynthetic gene cluster of tobramycin from Streptomyces tenebrarius An approach for cloning biosynthetic genes of 2-deoxystreptamine-containing aminocyclitol antibiotics: isolation of a biosynthetic gene cluster of tobramycin from Streptomyces tenebrarius