The identification of three new biosynthetic intermediates and one further biosynthetic enzyme in the clavulanic acid pathway

The identification of three new biosynthetic intermediates and one further biosynthetic enzyme in the clavulanic acid pathway Clavulanic acid, a β-lactamase inhibitor: biosynthesis and molecular genetics Biosynthesis and Molecular Genetics of Clavulanic Acid Studies on the biosynthesis of clavulanic acid. I. Incorporation of 13C-labelled precursors. Cloning, sequencing and disruption of a gene from Streptomyces clavuligerus involved in clavulanic acid biosynthesis Studies on the biosynthesis of clavulanic acid. III. Incorporation of DL-(3,4-13C2)glutamic acid. Two Sets of Paralogous Genes Encode the Enzymes Involved in the Early Stages of Clavulanic Acid and Clavam Metabolite Biosynthesis in <i>Streptomyces clavuligerus</i> Biosynthesis of clavam metabolites ORF17 from the Clavulanic Acid Biosynthesis Gene Cluster Catalyzes the ATP-dependent Formation of N-Glycyl-clavaminic Acid N-acyl derivatives of clavaminic acid produced by a mutant of Streptomyces clavuligerus