Halichlorine, an inhibitor of VCAM-1 induction from the marine sponge Halichondria okadai Kadata

Tetrahedron Letters
1996.0

Abstract

The novel alkaloid halichlorine was isolated from Halichondria okadai Kadota and its structure was elucidated by spectroscopic analysis. The relative stereochemistry was clarified by a detailed analysis of coupling constants and the NOESY spectrum. Halichlorine significantly inhibits VCAM-1 induction in cultured HUVE (human umbilical vein endothelial) cells. Copyright (C) 1996 Elsevier Science Ltd

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