Highly Efficient Total Synthesis of the Clostridium‐Derived anti‐MRSA Antibiotic Closthioamide

European Journal of Organic Chemistry
2011.0

Abstract

<jats:title>Abstract</jats:title><jats:p>The antibiotic closthioamide from <jats:italic>Clostridium cellulolyticum</jats:italic>, the first example of a secondary metabolite from strictly anaerobic bacteria, was synthesized by a versatile and highly efficient synthetic route. This starts from simple building blocks and involves convergent peptide coupling and polythionation.

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