<jats:title>Abstract</jats:title><jats:p>Phytochemical investigation of the EtOH extract of <jats:italic>Clausena vestita</jats:italic> D. D. <jats:sc>Tao</jats:sc> led to the isolation of one new coumarin, clauslactone U (<jats:bold>1</jats:bold>), and one new carbazole alkaloid, clauszoline N (<jats:bold>2</jats:bold>), together with 28 known compounds. The structures of these compounds were established by using MS and 1D‐ and 2D‐NMR techniques, and by comparison with known analogues.