Popolohuanone-A (l) end B (Z?) are two new sponge metabolites of composition G2Hw~N03. Their structures, which were determined by spectral and chemical correlations. comprise two molecules of a benzenoid moiety each linked to a rearranged drimane sesquiterpene and connected by en amino function. some c2* compounds, which are biogenetically derived from sesquiterpene and benzenoid moieties. have been isolated from marine sponges end brown algae.' Interest in these compounds has been heightened by reports of biological properties. which include in vivo sntileukemia activi ty.a &r m inhibition of replication of the AID8 v1rus.a and inhibition of tubulin polymerization.* A few nitrogenous derivatives have also been report&, in which the benzenoid moiety bears en amine function.s" We wish to describe two compounds, popolohuanone' A (i) and B (8). from a Dvsidea sp. sponge. in which two C,, entities, one a qu inone. the other a hydroquinone, derived from the known arenarone (2) and arenarol (5)s. Roth of these conrpunds are also present in the sponge.