New Cytotoxic Cembranolides from the Soft Coral Lobophytum michaelae

Chemical and Pharmaceutical Bulletin
2007.0

Abstract

Eleven new cytotoxic cembranolides, michaolides A-K (1-11), and crassolide (12) were isolated from the CH(2)Cl(2) extract of the Formosan soft coral Lobophytum michaelae. Their structures were established by extensive spectral analysis. The cytotoxicity of the isolates against selected cancer cells was measured in vitro.

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