The first phytochemical investigation of Oligomeris linifolia (Vahl) Macbr. led to the isolation of a new flavonol monoglycoside; isorhamnetin-40 -O-a-rhamnopyranoside in addition to ten compounds; one sterol, four flavonols, one nucleotide, two phenolic acids and two free sugars. Their structures were established on the basis of chemical and spectroscopic analysis and by comparison of their spectral data with those reported in the literature.