<jats:p> Two new chalcones, 3-hydroxy-3′,4′-dimethoxychalcone (1) and 3,2′-dihydroxy-3′,4′-dimethoxychalcone (2),were isolated from the flowers of Clerodendrum inerme (L.) Gaertn together with two known flavones, 7- O-methylwogonin (3) and eucalyptin (4). The structures of the new compounds 1 and 2 have been established by extensive 2D-NMR and ESI-TOFMS studies.