Activation and characterization of a cryptic gene cluster reveals a cyclization cascade for polycyclic tetramate macrolactams

Activation and characterization of a cryptic gene cluster reveals a cyclization cascade for polycyclic tetramate macrolactams Genome Mining of Marine-Derived Streptomyces sp. SCSIO 40010 Leads to Cytotoxic New Polycyclic Tetramate Macrolactams Genome Mining of Marine-Derived Streptomyces sp. SCSIO 40010 Leads to Cytotoxic New Polycyclic Tetramate Macrolactams Targeted Discovery of Polycyclic Tetramate Macrolactams from an Environmental <i>Streptomyces</i> Strain New polycyclic tetramate macrolactams from marine-derived Streptomyces sp. SCSIO 40060 Activation and characterization of a cryptic polycyclic tetramate macrolactam biosynthetic gene cluster Genome Mining and Activation of a Silent PKS/NRPS Gene Cluster Direct the Production of Totopotensamides Genome Mining and Activation of a Silent PKS/NRPS Gene Cluster Direct the Production of Totopotensamides Global and pathway-specific transcriptional regulations of pactamycin biosynthesis in Streptomyces pactum Targeted Discovery and Combinatorial Biosynthesis of Polycyclic Tetramate Macrolactam Combamides A–E