Constituents of Pongamia pinnata Isolated in a Screening for Activity to Overcome Tumor Necrosis Factor-Related Apoptosis-Inducing Ligand-Resistance

Chemical and Pharmaceutical Bulletin
2010.0

Abstract

In a search for natural products with activity to overcome tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-resistance, we performed the bioassay-guided fractionation of a semi mangrove, Pongamia pinnata, collected from Bangladesh, and isolated a new compound, (2S)-(2'',3'':7,8)-furanoflavanone (1), along with six known flavonoids (2-7). Two of the compounds significantly overcame TRAIL-resistance in human gastric adenocarcinoma (AGS) cell lines.

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