Seven indole alkaloids have been isolated from the cultured cyanophyte Hapalosiphon laingii. In addition to the known metabolites 12-epi-hapalindole E isonitrile [1], 12-epi-hapalindole C isonitrile [2], hapalindolinone A [3], and hapalindolinone B [4], H. laingii contains three new hapalindoles, 12-epi-hapalindole H [5], 12-epi-hapalindole G [6], and 12-epi-hapalindole Q isonitrile [7], the structures of which were elucidated by interpretation of their spectral data.